pentobarbital will lower the extent or impact of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Pitolisant publicity is reduced by 50% if coadministered with robust CYP3A4 inducers.pentobarbital will lessen the extent or influence of alprazolam by affecting hepatic/intestinal enzyme CYP